Biosimilar 3D ELISA is an advanced immunoassay that enhances traditional ELISA by incorporating a three-dimensional matrix to evaluate the similarity between biosimilars and their reference biologics.
Key Features:
- 3D Matrix Preparation:
- Uses a hydrogel or biocompatible material to capture proteins in their native conformation.
- Antigen Capture and Detection:
- Captures target proteins from both reference biologic and biosimilar samples.
- Uses primary and enzyme-linked secondary antibodies to detect conformational epitopes.
- Enhanced Analysis:
- Provides detailed insights into protein structure, including post-translational modifications and conformational integrity.
Applications:
- Comparative Analysis: Ensures biosimilar structural and functional equivalence to reference products.
- Quality Control: Monitors batch consistency.
- Research and Development: Optimizes biosimilar production processes.
Advantages:
- High Sensitivity and Specificity: Accurate detection of conformational epitopes.
- Comprehensive Structural Analysis: Holistic view of protein structure.
- High Throughput: Adaptable for large-scale screening.
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